Seek emergency medical attention or call the Poison Help line at A codeine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Opioid medicine can slow or stop your breathing, and death may occur.
A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:.
This list is not complete. Other drugs may affect codeine and promethazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc.
Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Codeine, guaifenesin, and pseudoephedrine is a combination medicine used to treat cough, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu. Codeine, guaifenesin, and pseudoephedrine may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to codeine, guaifenesin, or pseudoephedrine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
In some people, codeine breaks down rapidly in the liver and reaches higher than normal levels in the body. This can cause dangerously slow breathing and may cause death, especially in a child.
If you use codeine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breast-feed. Codeine can pass into breast milk and may cause drowsiness, breathing problems, or death in a nursing baby. Follow all directions on your prescription label.
Codeine can slow or stop your breathing. Never use codeine, guaifenesin, and pseudoephedrine in larger amounts, or for longer than prescribed. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Codeine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Selling or giving away codeine is against the law. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.
If you do not have a dose-measuring device, ask your pharmacist for one. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Do not take for longer than 7 days in a row. This content does not have an English version. This content does not have an Arabic version. See more conditions.
Products and services. Description and Brand Names Drug information provided by: IBM Micromedex US Brand Name Phenergan wCodeine Descriptions Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.
Please try again. It's best to stop drinking alcohol during the first few days of treatment until you see how codeine affects you. If you feel sleepy with codeine, stop drinking alcohol while you're taking it. Children aged 12 to 18 years can take codeine for pain or diarrhoea - but only if other medicines haven't worked. Use the lowest dose that works for no more than 3 days. If they still have symptoms after 3 days see a doctor. Codeine shouldn't be given to children aged 12 to 18 years if they have breathing problems or if they have had their tonsils or adenoids removed because of obstructive sleep apnoea.
If you're taking codeine for a short time and at normal doses, there's no firm evidence that it can reduce fertility. However if you've been taking it for a long time and you're concerned about your fertility, or you're trying to get pregnant, speak to a pharmacist or your doctor. The type of painkiller that's best depends on what type of pain you have.
If codeine doesn't get rid of your pain or becomes less effective, talk to your doctor. Codeine is a controlled medicine. This means there are extra rules on how it's prescribed and dispensed to make sure it's not given to the wrong person or misused.
However, this doesn't affect you as a patient. The rules only apply to the pharmacy that dispenses it. When you first take codeine, you'll probably feel sleepy for a few days.
But the sleepiness will wear off as your body gets used to the medicine. You might notice you're less alert. In this case, you might choose to have less than perfect pain relief as a trade-off.
Do not drive a car or ride a bike if codeine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions. This may be more likely when you first start taking codeine but could happen at any time - for example when starting another medicine. It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive.
Even if your ability to drive is not affected, the police have the right to request a saliva sample to check how much codeine is in your body. UK has more information on the law on drugs and driving. Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking codeine.
Codeine doesn't affect any type of contraception, including the combined pill or emergency contraception. But, if you are taking codeine because you have severe diarrhoea for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Look on the pill packet to find out what to do.
If you take recreational drugs, such as cannabis, cocaine and heroin while you're taking codeine, you're more likely to get the serious side effects of codeine including breathing difficulties, heart problems, seizures and even go into a coma.
Some recreational drugs, such as cannabis, will also increase codeine side effects such as sleepiness and dizziness. Taking heroin while you're on prescribed codeine is especially dangerous. You're more likely to get all the side effects of codeine, including addiction.
Tell your doctor if you think you may take recreational drugs while you're on codeine. Page last reviewed: 27 November Next review due: 27 November Codeine On this page About codeine Key facts Who can and can't take codeine How and when to take it Taking codeine with other painkillers Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions.
About codeine Codeine is a painkiller. Help us improve our website Can you answer a quick question about your visit today? Codeine works by stopping pain signals from travelling along the nerves to the brain. The most common side effects of codeine are constipation, feeling sick nausea and feeling sleepy. It's possible to become addicted to codeine, but your doctor will explain how to reduce the risks of becoming addicted. If you need to take codeine for more than a few weeks, your treatment plan may include details of how and when to stop taking this medicine.
It may be best not to drink alcohol while taking codeine as you're more likely to get side effects like feeling sleepy. Do not give codeine to children under 12 years old. Only give codeine to children aged 12 to 18 years if everyday painkillers like paracetamol and ibuprofen haven't worked.
Codeine can be taken by adults and children aged 12 years and older. Tell your doctor before starting the medicine if you have: had an allergic reaction to codeine or any other medicines in the past a lung problem a head injury adrenal gland problems an illness which causes seizures an addiction to alcohol an underactive thyroid gland kidney or liver problems gallstones an enlarged prostate low blood pressure myasthenia gravis a rare illness that causes muscle weakness symptoms of ulcerative colitis a bowel condition Do not give codeine to children who are under 18 years old and have had their tonsils or adenoids removed because of a sleep problem called obstructive sleep apnoea.
Different types of codeine Codeine comes as: tablets - these contain 15mg, 30mg or 60mg of codeine a liquid that you swallow - this contains 25mg of codeine in a 5ml spoonful cough syrup - this contains 15mg of codeine in a 5ml spoonful an injection usually given in hospital If you're taking codeine as a liquid, it will come with a plastic spoon or syringe to help you measure the correct amount.
Dosage The usual dose of codeine is 15mg to 60mg. The usual dose for treating pain: adults usually take one or two 30mg tablets every 4 hours, up to a maximum of 8 tablets mg in 24 hours children aged 12 to 17 years usually take one or two 30mg tablets or one or two 5ml spoonfuls of liquid every 6 hours elderly people or people with kidney or liver problems usually take a 15mg tablet every 4 hours The usual dose for treating diarrhoea: adults usually take one or two 30mg tablets or one or two 5ml spoonfuls of liquid children aged 12 to 17 years usually take one or two 30mg tablets or one or two 5ml spoonfuls of liquid elderly people or people with kidney or liver problems usually take a 15mg tablet You can take this dose 3 or 4 times a day.
The usual dose for treating a cough: adults and children usually take one or two 5ml spoonfuls of cough syrup 3 or 4 times a day.
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