Why gynaecomastia in hyperthyroid

Recognition of this unusual presentation of hypothyroidism will help to avoid and reduce unnecessary investigations or surgical procedure as the condition is completely reversible with anti-thyroid treatment. Source of Support: Nil. Conflict of Interest: None declared.

National Center for Biotechnology Information , U. Indian J Endocrinol Metab. Author information Copyright and License information Disclaimer. Corresponding Author: Dr. E-mail: moc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

This article has been cited by other articles in PMC. Abstract Gynaecomastia is a well-recognized manifestation of thyrotoxicosis occurring in a widely variable percentage. Keywords: Gynaecomastia, thyrotoxicosis, sex hormone binding globulin. An endocrine and histological investigation. J Clin Endocrinol Metab. No nodularity could be appreciated bilaterally and no fluid could be milked from the nipple areas.

There was no axillary lymphadenopathy. Complete blood count, metabolic profile and liver functions were essentially normal. Figure 1. Thyroid uptake study revealed slight enlargement of right upper lobe and homogeneous uptake in both lobes.

There were no hot or cold nodules. Six hour uptake was computed at Figure 2. Mammography showed increased density in the retro-areolar area bilaterally, representing ductal prominence secondary to gynecomastia.

No evidence of tumor mass density was seen. No abnormal calcifications were seen. Figures — 2 and 3. Figure 3. Tests of endocrine functions revealed elevated LH, estradiol and a grossly elevated testosterone levels.

But free testosterone was in fact reduced and sex hormone binding globulin SHBG was abnormally elevated.

Table- 2. Figure 4 Tbl2. The patient was sent for a radio Iodine ablation of the thyroid. Gynecomastia is a benign proliferation of the glandular tissue of the male breast.

It could be diagnosed on exam as a palpable mass of tissue at least 0. Figure 1. The pictures showed milky discharge from right breast, before a , during b , and after c gentle manipulation of the nipple. Table 1. References K. Becker, J. Winnacker, M. Matthews, and G. Higgins Jr. Ashkar, W. Smoak III, A. Gilson, and R. Sanyal, D. Dutta, K. Shivprasad, S. Ghosh, S. Mukhopadhyay, and S. S—S, View at: Google Scholar D. Kleinberg, G. Oxford University Press is a department of the University of Oxford.

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Volume Gynecomastia and Hyperthyroidism. An Endocrine and Histological Investigation. Oxford Academic. Google Scholar.