It is methylglyoxal or MGO that gives manuka honey its wonderful antibacterial properties and makes manuka honey superior to other types of honey for medicinal purposes. The higher the concentration, the more antibacterial activity. Dietary methylglyoxal is resistant to heat, body fluids, light, and enzymatic activity , thus considered very stable. Manuka honey is not good only because of its MGO component, but because of its low pH, high content of sugars, peroxide activity, enzyme and polyphenols content.
Check out our raw NZ manuka honey. Remember me Log in. Lost your password? Posted on August 14, July 3, by Rachel. So both are equally useful in helping customers know that their honey is genuine. Manuka honey with the highest ratings is the most potent in terms of some important health benefits. The very strongest grades are highly antibacterial and able to fight off dangerous infections.
The Medical grade Manuka honey used in hospitals is further purified to remove any trace of contaminants. However, Medical grade Manuka is not eaten. Instead but applied topically. There isn't conclusive evidence that eating manuka honey this potent would be any better for you than lower grade honey.
That's great news for the budget! It is important to remember that research into Manuka Honey is ongoing. The specific health benefits of Manuka Honey is still the subject of debate.
Research into Manuka honey has revealed many unique properties, and scientists are only just starting to understand the healing benefits of this extraordinary natural product.
This has led to increasing demand and high prices for quality honey. That's why the NZ government developed strict guidelines for labelling. Getting to know your honey producers is the best way to ensure that your Manuka honey is genuinely what it says it is. This is particularly important if you are buying Manuka honey in New Zealand.
Unfortunately, the strict labelling rules do not apply to Manuka Honey sold in New Zealand. Always choose ethical and sustainable beekeepers who hold themselves to the same high standards, no matter where their honey is sold.
It also pays to do your homework and find producers you can really trust. With deep, complex flavours and goodness in every teaspoon, it is entirely up to you whether to stir it into your tea, spread it on toast, or lick it straight off the spoon.
Most raw honey has antibacterial properties, but the high levels of MGO give this honey an extra antibacterial punch. The star of this side is the Sweet Tahini Sauce which simply uplifts often boring winter vegetables. We love this served with Grilled Haloumi or placed upon a generous dollop of Hummus for an easy, yet beautiful Winters meal.
It is unknown whether or not these differences in MIC would have a significant clinical impact, such as for topical treatment of wound infections. Studies correlating antimicrobial susceptibility testing results with clinical outcomes are lacking, but may be beneficial to developing best practices in using Manuka honey for its antibiotic activity.
Manuka honey exhibited antimicrobial activity against a spectrum of MDR and non-MDR bacterial organisms isolated from wound sites, with greater potency against staphylococcal organisms compared to gram-negative bacteria. We conclude that UMF grade, as an indicator of MGO content and honey quality, may be misleading to the consumer as it may not necessarily correlate with antibacterial efficacy of the Manuka honey at the time of purchase or the time of use. Studies investigating in vivo outcomes of Manuka honey of different UMF grades while confirming MGO and DHA content are needed to advance our understanding of use of Manuka honey for medicinal purposes.
Despite these concerns, natural products such as Manuka honey are promising as alternative agents in combatting MDR bacterial infections. Categories and sub-categories of organism as discussed in the text are also indicated. We thank Dr. Susan Butler-Wu for provision of a portion of the bacterial isolates used in this study.
National Center for Biotechnology Information , U. PLoS One. Published online Oct Rosemary C. Filippo Giarratana, Editor.
Author information Article notes Copyright and License information Disclaimer. Competing Interests: The authors have declared that no competing interests exist. Received Aug 19; Accepted Oct This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article has been cited by other articles in PMC. Abstract Honey has been used as a traditional remedy for skin and soft tissue infections due to its ability to promote wound healing. Background Honey has long been used as a wound salve and has been found experimentally to stimulate tissue regeneration, facilitate wound debridement, reduce inflammation, and exert antibacterial properties [ 1 ].
Open in a separate window. Fig 1. Discussion The increasing incidence of multi-drug resistant bacterial infections worldwide poses new challenges which have led to a renewed interest in Manuka honey as an alternative antibiotic agent [ 3 , 18 ].
Conclusions Manuka honey exhibited antimicrobial activity against a spectrum of MDR and non-MDR bacterial organisms isolated from wound sites, with greater potency against staphylococcal organisms compared to gram-negative bacteria. Supporting information S1 Table Minimal inhibitory concentrations of 3 different UMF grades of Manuka honey for bacterial isolates.
XLSX Click here for additional data file. Acknowledgments We thank Dr. Funding Statement The authors received no specific funding for this work.
Data Availability All relevant data are within the manuscript and its Supporting Information files. References 1. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. J Tissue Viability. Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review.
Iran J Basic Med Sci. Front Microbiol. Screening bioactivity and bioactive constituents of Nordic unifloral honeys. Food Chem. The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Manuka honey inhibits cell division in methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. The effect of manuka honey on the structure of Pseudomonas aeruginosa. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka Leptospermum scoparium honeys from New Zealand.
Mol Nutr Food Res. Antimicrobial effect of different types of honey on. Saudi J Biol Sci.
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